![]() We also identified the LncRNA differentially expressed in LCLC compared to lung squamous carcinoma (LUSC) and Lung-adenocarcinoma (LUAD). Guilt by association analysis using genes correlating with differentially expressed LncRNAs identified several cancer-associated pathways, suggesting the role of these deregulated LncRNA in LCLC biology. Based on receiver operating characteristic (ROC) analysis, we showed that the top five differentially expressed LncRNAs were able to differentiate between LCLC and normal samples with high sensitivity and specificity. Among 1794 expressed LncRNAs, 11 were overexpressed and 14 were downregulated in LCLC compared to normal samples. Using 10 LCLC samples, we found that 18% of all the annotated LncRNAs are expressed in LCLC samples. The RNA-seq profile of LCLC and other non-small cell lung carcinoma (NSCLC) was downloaded from Gene Expression Omnibus (GEO) and analyzed. In this study, we aim to identify long non-coding RNAs (LncRNAs) expression pattern specific to LCLC. Recently, RNA-seq based studies have revealed major genomic aberrations in LCLC. Undifferentiated large cell lung carcinoma (LCLC) accounts for 2.9-9% of total lung cancers. Unravelling the Long Non-Coding RNA Profile of Undifferentiated Large Cell Lung Carcinoma. ![]()
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